Meet Us At ISCT

Meet BioInVision application specialists at the 2024 ISCT Conference Vancouver, Canada from May 29-31, 2024. Learn how to use CryoViz Imaging to advance your research.

Selected Publications on CryoViz Imaging


  1. Wuttisarnwattana, P, et al. "Assessment of therapeutic role of mesenchymal stromal cells in mouse models of graft-versus-host disease using cryo-imaging." Scientific Reports (2023): 13(1), 1698.
  2. Liu, Y, et al. "Deep learning multi-organ segmentation for whole mouse cryo-images including a comparison of 2D and 3D deep networks." Scientific Reports (2022): 12(1), 15161.
  3. Wang, Y, et al. "Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain." Pain (2022): 163(6), 1091-1101.
  4. Scarneo, S, et al. "Expression of membrane Hsp90 is a molecular signature of T cell activation." Scientific Reports (2022): 163(6), 12(1), 18091.
  5. Owen, A, et al. "PDGFRα/Sca-1 Sorted Mesenchymal Stromal Cells Reduce Liver Injury in Murine Models of Hepatic Ischemia-Reperfusion Injury." Stem Cells (2022): 40(11), 1056-1070.
  6. Curtis, A, et al. "Galleria mellonella Larvae as a Model for Investigating Fungal—Host Interactions." Frontiers in Fungal Biology (2022): 18.
  7. Qiao, P, et al. "Magnetic resonance molecular imaging of extradomain B fibronectin enables detection of pancreatic ductal adenocarcinoma metastasis." Magnetic Resonance Imaging (2022): 86, 37-45.
  8. Liu, Y, et al. "Quantitative analysis of metastatic breast cancer in mice using deep learning on cryo-image data." Scientific Reports (2022): 11(1), 1-15.
  9. Metheny, L, et al. "Human multipotent adult progenitor cells effectively reduce graft‐vs‐host disease while preserving graft‐vs‐leukemia activity following experimental, allogeneic bone marrow transplantation." Stem Cells (2021): 39(11), 1506-1519.
  10. Carty, F, et al. "IFN‐γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease." Stem Cells Translational Medicine (2021): 10(11), 1561-1574.
  11. Park, H, et al. "Safety of Intraovarian Injection of Human Mesenchymal Stem Cells in a Premature Ovarian Insufficiency Mouse Model." Cell Transplantation (2021): 0963689720988502.
  12. Fracassi, A, et al. "LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis." Chemical Science (2020): Vol. 11, no. 44, pp. 11998-12008.
  13. Wang, X, et al. "Photodynamic therapy is an effective adjuvant therapy for image-guided surgery in prostate cancer." Cancer Research (2020): 80, no. 2.
  14. Haber, T, et al. "Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles." Proceedings of the National Academy of Sciences (2020)
  15. Covarrubias, G, et al. "PTPmu-targeted nanoparticles label invasive pediatric and adult glioblastoma." Nanomedicine: Nanotechnology, Biology and Medicine (2020): 102216.
  16. Wuttisarnwattana, P, et al. "Cryo-imaging of Stem Cell Biodistribution in Mouse Model of Graft-Versus-Host-Disease." Annals of biomedical engineering (2020): 1-10.
  17. Sheehan, G, et al. "Candida albicans increases the pathogenicity of Staphylococcus aureus during polymicrobial infection of Galleria mellonella larvae." Microbiology (2020): mic000892.
  18. Sierra-Parraga, J, et al. "Mesenchymal stromal cells are retained in the porcine renal cortex independently of their metabolic state after renal intra-arterial infusion." Stem cells and development (2019): 28(18), 1224-1235.
  19. Romanelli, P, et al. "Extracellular Vesicles Can Deliver Anti-Inflammatory and Anti-Scarring Activities of Mesenchymal Stromal Cells after Spinal Cord Injury." Frontiers in Neurology (2019): 10, 1225.
  20. Gallaghera, D, et al. "Mesenchymal stromal cells modulate peripheral stress-induced innate immune activation indirectly limiting the emergence of neuroinflammation-driven depressive and anxiety-like behaviors." Biological psychiatry (2019): 86(9), 712-724.
  21. Masterson, C, et al. "Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns." Intensive care medicine experimental (2019): 7(1), 41.
  22. Sheehan, G, et al. "Utilization of Galleria mellonella larvae to characterize the development of Staphylococcus aureus infection." Microbiology (2019): 165, no. 8.
  23. Haldar, D, et al. "Study of anti-fibrotic activity of human umbilical-cord tissue-derived mesenchymal stromal cells during fibrogenesis or resolution in murine models of liver fibrosis." Journal of Hepatology (2019): Vol. 70, pp. E194-E194.
  24. Geiger, S, et al. "Alpha-1 antitrypsin-expressing mesenchymal stem/stromal cells confer a long-term survival benefit in a mouse model of lethal GvHD." Molecular Therapy (2019): 27(8), 1436-1451.
  25. MacCannell, Amanda DV, et al. "Identification of a lipid-rich depot in the orbital cavity of the 13-lined ground squirrel." Journal of Experimental Biology (2019): jeb-195750.
  26. Sheehan, Gerard, and Kevin Kavanagh. "Proteomic Analysis of the Responses of Candida albicans during Infection of Galleria mellonella Larvae." Journal of Fungi 5.1 (2019): 7.
  27. Zhang, Qi, Terry Peters, and Aaron Fenster. "Layer-based visualization and biomedical information exploration of multi-channel large histological data." Computerized Medical Imaging and Graphics (2019).
  28. Ngo, Lucy, Lillian E. Knothe, and Melissa L. Knothe Tate. "Knee Joint Tissues Effectively Separate Mixed Sized Molecules Delivered in a Single Bolus to the Heart." Scientific reports 8.1 (2018): 10254.
  29. Parkins, Katie M., et al. "Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis." Scientific reports8.1 (2018): 8930.
  30. Sheehan, Gerard, Gráinne Clarke, and Kevin Kavanagh. "Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis." BMC microbiology 18.1 (2018): 63.
  31. Qutaish, Mohammed Q., et al. "Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases." International journal of biomedical imaging2018 (2018).
  32. Carty, Fiona, et al. "Multipotent adult Progenitor cells suppress T cell activation in In Vivo Models of homeostatic Proliferation in a Prostaglandin e2-Dependent Manner." Frontiers in immunology 9 (2018).
  33. de Witte, Samantha FH, et al. "Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells." Stem Cells36.4 (2018): 602-615.
  34. Wu, Chunying, et al. "Discovery of 1, 2, 3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System." Journal of medicinal chemistry 60.3 (2017): 987-999.
  35. Perera, V. S., et al. "One-pot synthesis of nanochain particles for targeting brain tumors." Nanoscale 9.27 (2017): 9659-9667.
  36. de Witte, Samantha FH, et al. "Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease." Stem Cell Research & Therapy 8.1 (2017): 140.
  37. Prabhu, David, et al. "Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation." Journal of Medical Imaging 3.2 (2016): 026004.
  38. Parkins, Katie M., et al. "A multimodality imaging model to track viable breast cancer cells from single arrest to metastasis in the mouse brain." Scientific reports 6 (2016): 35889.
  39. Saat, T. C., et al. "Fate and effect of intravenously infused mesenchymal stem cells in a mouse model of hepatic ischemia reperfusion injury and resection." Stem cells international 2016 (2016).
  40. Schmuck, Eric G., et al. "Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model." Stem Cells Translational Medicine (2016): sctm-2015.
  41. Kobes, Joseph E., et al. "Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor." Pancreas 45.8 (2016): 1158-1166.
  42. Wuttisarnwattana, Patiwet, et al. "Automatic stem cell detection in microscopic whole mouse cryo-imaging." IEEE transactions on medical imaging 35.3 (2016): 819-829.
  43. Zanotti, Lucia, et al. "Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1."Leukemia (2016).
  44. Doolittle, Elizabeth, et al. "Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis." ACS nano 9.8 (2015): 8012-8021.
  45. DePaul, Marc A., et al. "Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury." Scientific reports 5 (2015).
  46. Auletta, Jeffery J., et al. "Human Mesenchymal Stromal Cells Attenuate Graft‐Versus‐Host Disease and Maintain Graft‐Versus‐Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation." Stem cells33.2 (2015): 601-614.
  47. Zhou, Zhuxian, et al. "MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent." Nature communications 6 (2015).
  48. Qutaish, Mohammed Q., et al. "Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme." Molecular Imaging and Biology 14.5 (2012): 572-583.
  49. Burden-Gulley, Susan M., et al. "Novel cryo-imaging of the glioma tumor microenvironment reveals migration and dispersal pathways in vivid three-dimensional detail." Cancer research 71.17 (2011): 5932-5940.
  50. Gargesha, Madhusudhana, et al. "Visualization of color anatomy and molecular fluorescence in whole-mouse cryo-imaging." Computerized Medical Imaging and Graphics 35.3 (2011): 195-205.
  51. Roy, Debashish, et al. "Multi-scale characterization of the PEPCK-C mus mouse through 3D Cryo-imaging." Journal of Biomedical Imaging 2010 (2010): 5.
  52. Steyer, Grant J., et al. "Removal of out-of-plane fluorescence for single cell visualization and quantification in cryo-imaging." Annals of biomedical engineering 37.8 (2009): 1613-1628.
  53. Roy, Debashish, et al. "3D cryo‐imaging: a very high‐resolution view of the whole mouse." The anatomical record 292.3 (2009): 342-351.
  54. Nguyen, M. S., et al. "Ex vivo characterization of human atherosclerotic iliac plaque components using cryo‐imaging." Journal of microscopy 232.3 (2008): 432-441.


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New Imaging Device Enables Scientists to See Tumor Cells Traveling in the Brain

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